Endothelial-to-Mesenchymal Transition and MicroRNA-21
نویسندگان
چکیده
منابع مشابه
Endothelial-to-mesenchymal transition and microRNA-21: the game is on again.
In the presence of any left ventricular dysfunction, be it systolic or diastolic, there is an increased risk of developing heart failure (HF). Survival expectancy has been improved in HF patients with reduced systolic function, but not for those with a normal ejection fraction.1,2 Moderate or severe diastolic dysfunction, which is predictive of all-cause death, has a prevalence of 7% in asympto...
متن کاملTransforming growth factor-β-induced endothelial-to-mesenchymal transition is partly mediated by microRNA-21.
OBJECTIVE MicroRNAs are a class of small ribonucleotides regulating gene/protein targets by transcript degradation or translational inhibition. Transforming growth factor-β (TGF-β) is involved in cardiac fibrosis partly by stimulation of endothelial-to-mesenchymal transition (EndMT). Here, we investigated whether microRNA (miR)-21, a microRNA enriched in fibroblasts and involved in general fibr...
متن کاملMicroRNA Regulation of Epithelial to Mesenchymal Transition
Epithelial to mesenchymal transition (EMT) is a central regulatory program that is similar in many aspects to several steps of embryonic morphogenesis. In addition to its physiological role in tissue repair and wound healing, EMT contributes to chemo resistance, metastatic dissemination and fibrosis, amongst others. Classically, the morphological change from epithelial to mesenchymal phenotype ...
متن کاملEndothelial-to-mesenchymal transition in pulmonary hypertension.
BACKGROUND The vascular remodeling responsible for pulmonary arterial hypertension (PAH) involves predominantly the accumulation of α-smooth muscle actin-expressing mesenchymal-like cells in obstructive pulmonary vascular lesions. Endothelial-to-mesenchymal transition (EndoMT) may be a source of those α-smooth muscle actin-expressing cells. METHODS AND RESULTS In situ evidence of EndoMT in hu...
متن کاملEndothelial-to-mesenchymal transition drives atherosclerosis progression.
The molecular mechanisms responsible for the development and progression of atherosclerotic lesions have not been fully established. Here, we investigated the role played by endothelial-to-mesenchymal transition (EndMT) and its key regulator FGF receptor 1 (FGFR1) in atherosclerosis. In cultured human endothelial cells, both inflammatory cytokines and oscillatory shear stress reduced endothelia...
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ژورنال
عنوان ژورنال: Arteriosclerosis, Thrombosis, and Vascular Biology
سال: 2012
ISSN: 1079-5642,1524-4636
DOI: 10.1161/atvbaha.111.242008